Objectives

	Explain the physiologic basis of the alveolar gas equation and calculate an A-a gradient.
	Discuss the relationship between PaO₂, O₂ saturation, hemoglobin, and O₂ content and therapeutic interventions that affect the relationship.
	Calculate tissue oxygen consumption and describe its clinical application.
	Discuss the clinical significance of the oxyhemoglobin dissociation curve.
	Define and calculate the following parameters: CaO2, DO2, VO2, ERO2, A-a, a/A, PaO2/FIO2.
	Explain the relationship between alkalosis and oxyhemoglobin affinity.
	Critique the use of supraphysiologic values for DO2 and VO2 as clinical endpoints.
	Outline the physiologic rationale for SvO2 monitoring.
	Define hypoxic pulmonary vasoconstriction and explain its clinical significance.
	Contrast an intrapulmonary shunt with a deadspace, and discuss the role of each on gas exchange.
	Utilize arterial blood gases as a tool for ventilator management.