OXYGEN TRANSPORT AND UTILIZATION

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OBJECTIVES

Explain the physiologic basis of the alveolar gas equation and calculate an A-a gradient.

Discuss the relationship between PaO2, O2 saturation, hemoglobin, and O2 content and therapeutic interventions that affect the relationship.

Calculate tissue oxygen consumption and describe its clinical application.

Discuss the clinical significance of the oxyhemoglobin dissociation curve.

Define and calculate the following parameters: CaO2, DO2, VO2, ERO2, A-a, a/A, PaO2/FIO2.

Explain the relationship between alkalosis and oxyhemoglobin affinity.

Critique the use of supraphysiologic values for DO2 and VO2 as clinical endpoints.

Outline the physiologic rationale for SvO2 monitoring.

Define hypoxic pulmonary vasoconstriction and explain its clinical
significance.

Contrast an intrapulmonary shunt with a deadspace, and discuss the
role of each on gas exchange.

Utilize arterial blood gases as a tool for ventilator management.


 

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